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The Ontario Consortium for
Adaptive Interventions in
Radiation Oncology

What is OCAIRO?

The Ontario Consortium for Adaptive Interventions in Radiation Oncology (OCAIRO), funded by the Ontario Research Fund, sets out to accelerate the development and application of innovative adaptive methods in radiation therapy through focused scientific, technical, and clinical developments in four domains: (i) Imaging and Instrumentation for Adaptive Radiation Therapy; (ii) Adaptive Radiation Therapy Processes; (iii) Validation of Image Signal and Dose Accumulation in Adaptive RT; and (iv) Open Source Software Platforms and Databases for the Adaptive Process. These initiatives require the engagement of physicists, oncologists, engineers, and industry partners to develop the processes and systems that will allow safe and effective execution of the adaptive approach. This consortium brings together the depth and breadth of Ontario’s radiation oncology research community), and best-in-class industrial collaborators with financial commitments to accelerate innovations in radiation oncology practice to clinical application. With this effort, Ontario stands to lead the world in the application of adaptive radiation therapy for the benefit of its patient population.

Four themes within OCAIRO are shown below.  Please click on the name to view more information.

Imaging and Instrumentation for Adaptive Radiation Therapy

OCAIRO focuses on innovative developments in imaging, with leading industry partners to support the adaptive therapy paradigm—with the common goal of enabling adaptive radiotherapy that is tailored to the ongoing changes in the patient’s anatomy over the duration of a full course of radiotherapy.

Adaptive Radiation Therapy Processes

OCAIRO research activities focus on novel strategies for use of 3D/4D imaging and adaptation technologies to improve precision of dose distribution delivery while maintaining high patient throughput with a variety of platforms to maximize on commercial potential and to offer broad bases for beta testing of novel processes that leverage technology enabling the iteration of the ‘image, plan, and treat’ approach.

Validation of Image Signal and Dose Accumulation in Adaptive RT

This team will face the challenging issues of validation of image signals, deformation methods, and dose accumulation. The assurance of the accuracy of adaptive technologies must be completed for the clinical implementation of adaptive radiation therapy.

Open Source Software Platforms and Databases for the Adaptive Process

The OCAIRO project delivers on the creation of software tools for maturing adaptive radiation therapy methods and sharing valuable datasets across the community. Other interventions (neurosurgery) have been accelerated by the development of open-source platforms. The broad representation of the OCAIRO consortium will provide a critical mass for driving such a development for radiation therapy.